Ray Mak, Associate Professor of Radiation Oncology at Harvard Medical School, shared on X:
“Just out JACC Cardio Oncology, we intricately map radiation exposure from radiotherapy for lung cancer to different sub-structures of he heart to predict the risk of 5 different classes of cardiac arrhythmias, pointing to possibly distinct pathophys pathways.
Key specific sub-structures at risk included pulmonary veins and coronaries (and atria), with very different dose thresholds! Key question remains is whether the coronary association is due to a ischemia pathway leading to arrhythmia vs. dosimetric surrogate for a conduction sub-structure.
We used AI segmentation tools to help us uncover these connections. Nice example of how collaboration between radiation oncology, EP, cardiology, cardio-oncology , AI scientists drives new insights! The impact of radiotherapy on the conduction system is more complex than we thought…”
Association of Cardiac Substructure Radiation Dose With Arrhythmia: Time to Move Away From Mean Dose
Authors: Gerard Walls and Alan McWilliam
Source: Ray Mak/X