Myeloma Paper of the Day, April 29th, suggested by Robert Orlowski

Myeloma Paper of the Day, April 29th, suggested by Robert Orlowski

Robert Orlowski, Deputy Chair of Lymphoma/Myeloma, Vice Chair of MM Research and Florence Maude Thomas Cancer Research Professor at the University of Texas MD Anderson Cancer Center, shared a post on X:

“Myeloma Paper of the Day: Immune profiling of smoldering myeloma patients treated with vaccine targeting XBP1/CD138/CS1 + HDACi citarinostat +/- len finds more B intermediate, CD8 effector memory and B memory cells, fewer plasmablasts and CD4 prolif. cells.”

“Immune profiling of smoldering multiple myeloma patients treated in a phase lb study of PVX-410 vaccine targeting XBP1/CD138/CS1 antigens, and citarinostat, a histone deacetylase inhibitor (HDACi) with and without lenalidomide”

Authors: Diana Cirstea, Rajib Shome, Mehmet Samur, Srikanth Talluri, Joseph Connolly, Cristiana Costa Chase, Ehsan Malek, Ruben Niesvizky, Paul Richardson, Noopur Raje et al.

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